Correspondence between John Charnley and C.M.W. Laboratories Limited relating to Charnley’s approach to C.M.W. as a potential supplier of cold cure acrylic cement for use in bonding metallic replacements to living bone. There is discussion of manufacture, conditions, requirements, production, packaging, supply, setting time, composition, sterilization, testing, containers, marketing and promotional material.
There is also reference to the effects of irradiation, visibility on a radiograph, potential side effects, securing a patent, and Charnley’s intention of writing an article on the product’s technical aspects.
There is correspondence relating to discussion of the special features of the product, and of the FDA and Swiss drug administration requirements for instructions, packaging and labelling. There is also discussion of the effect of the cement on blood pressure, experimentation on animals, releasing details on the chemical formula of the cement, and sale of the product in North America.