The collection contains correspondence between Abraham Hume and the art dealers Giovanni Maria Sasso, in Venice, and Giovanni Antonio Armano, in Bologna, in addition to a few other agents and dealers based in Italy. The correspondence relates to the acquisition of works for Hume's art collection as well as mineralogical specimens and includes discussion of works by, or attributed to Tintoretto, Titian, Giorgione, and others which were offered to or acquired by Abraham Hume.
The collection also includes lists of paintings in Hume's collection, and later at Ashridge Park, where they passed by inheritance to his grandson Viscount Alford (1812-1851).
There are also hand-written and typed summaries [in English] of the contents of some of the letters, written by Robert Cust, in addition to transcripts of the letters from Giovanni Maria Sasso to Abraham Hume, made by Linda Borean in 2003.