Huntington's manuscript collection contains many rare and early items. There are over 300 Arabic manuscripts, whose subjects include astronomy, geography, history, language, law, mathematics and medicine. One extraordinary item is an illustrated manuscript on weaponry commissioned by Saladin (fl 12th century) for his own library (MS. Huntington 264). Among the 212 Hebrew manuscripts is the Mishneh Torah of Maimonides (1135-1204), with the author's signature (MS. Huntington 80), bought by Huntington while acting as chaplain to the English merchants in Aleppo.
In addition to the Arabic and Hebrew material, the collection includes 31 Syriac and 29 Coptic manuscripts, as well as manuscripts in Mandaean, Persian, Turkish, and Uighur. A number of Christian works in Arabic, Coptic and Syriac also feature, reflecting Huntington's interest in the Eastern churches.
The full shelfmarks of the collection are as follows: MSS. Huntington 1-13, 15-113, 115-23, 125-30, 132-229, 231-64, 266-71, 273-310, 312-456, 458-525, 527-67, 569-92, 594-604, 606-16, 617-20 (R), 621, 622 (R), 623, 630-3; MSS. Auct. E. 5. 2, E. 5. 6, E. 5. 8-12, E. 5. 15, E. 5. 17; MSS. Huntington Add. B (R), D (R), E-G (R); MSS Huntington donat. 1-35.