The papers are not extensive, probably because of the period in Australia. They consist almost entirely of research notes and related correspondence arranged by topic. Ogston's main research interests included the thermodynamics of biological systems, particularly in relation to connective tissue, and the use of physico-chemical methods to study the size, weight and structure of molecules. Also represented is the important 'three-point attachment' contribution to stereochemistry. There is little biographical material or personal correspondence.
The supplementary papers provide documentation of some of Ogston's later scientific research, including research initiated on visits to Uppsala in September 1977 and the Institute of Cancer Research, Philadelphia, 1978-1979. There are also correspondence, notes and a draft paper with H.A. Krebs on the use of isotopic labels to measure the rate of gluconeogenesis, 1977-1980.